Loos, september 21st 2023

World Alzheimer’s day 2023




Alzprotect, a biopharmaceutical company based in Lille, is currently testing an innovative drug against a neurodegenerative disease closely related to Alzheimer's disease. The very good results obtained have allowed Alzprotect to extend the clinical trial of this treatment for 6 months, and to prepare a larger scale study. The molecule being tested, AZP2006, offers a mode of action radically different from existing treatments, and brings considerable hope to all the patients concerned. Alzprotect is financed by the Xerys Invest funds (Paris)

Alzprotect, a French biopharmaceutical company, is testing an innovative drug against Progressive Supranuclear Palsy (PSP), a neurodegenerative disease closely related to Alzheimer's disease.

The molecule being tested, AZP2006, proposes a fundamentally distinct mechanism of action compared to existing treatments: it is the first to target all the causes of neurodegeneration, by stimulating the action of a protein essential to the functioning of the brain, Progranulin. This mode of action makes the molecule capable of acting on several neurodegenerative diseases.

The Lille University Hospital, the Pitié-Salpêtrière Hospital, and the Adolphe de Rothschild Foundation Hospital are participating in the clinical trials.


The clinical trials, currently in phase 2a, were conducted in three centers: the Lille University Hospital under the direction of Professor Defebvre, the Pitié-Salpêtrière Hospital with Professor Corvol, and the Adolphe de Rothschild Foundation Hospital with Dr. Obadia. The study revealed promising results: the treatment was perfectly tolerated, And the first signs of efficacy have been observed and will need to be confirmed in the upcoming phase 2/3 study. 

These good results have allowed the extension of the trial: patients will be able to benefit from the treatment for an additional 6 months, thanks to the approval granted by the National Agency for the Safety of Medicines (ANSM) and the Committee for the Protection of Persons (CPP). Furthermore, Alzprotect is preparing a larger phase 2/3 trial, in Europe and the United States, to test the efficacy of the molecule over a 12-month treatment period.

A molecule capable of targeting several neurodegenerative diseases.


« The extension of this phase 2a clinical trial is good news for the patients who participated in it and will reinforce the promising results for the AZP2006 molecule, says Pr. Jean-Christophe Corvol, Professor of Neuropharmacology and head of the Neurology Department at Pitié-Salpêtrière. More generally, this decision represents additional hope for patients suffering from PSP, a debilitating and rare neurodegenerative disease, for which no treatment has been able to halt the progression to date. ».

« This progress concerns not only the patients involved, but also potentially people suffering from other neurodegenerative diseases," adds Philippe Verwaerde, CEO of Alzprotect. "We plan to launch trials with patients suffering from Alzheimer's disease, or even Parkinson's disease, very soon».

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